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[89Zr]Zr-DFO-AR20.5
- Development stage
- Preclinical
- Lead developer
- Hunter College
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[89Zr]Zr-DFO-AR20.5 is an investigational **MUC1-targeted immunoPET radiotracer** consisting of the AR20.5 anti-MUC1 monoclonal antibody conjugated to the desferrioxamine chelator and radiolabeled with positron-emitting zirconium-89. It is designed for intravenous PET imaging of MUC1-expressing tumors, rather than for therapeutic radiation delivery. In mouse models of subcutaneous and orthotopic MUC1-expressing ovarian cancer, including metastatic lesions, the tracer demonstrated tumor uptake and favorable tumor-to-background contrast. ([mdpi.com](https://www.mdpi.com/1420-3049/25/10/2315))
- Other names
- 89Zr-DFO-AR20.589Zr-labeled AR20.5
02
Targets
MUC1 (Mucin-1 Antigen)
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